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Article

Using de novo assembly to identify structural variation of eight complex immune system gene regions.

PLoS computational biology - 1 Aug 2021

Zhang Jia-Yuan, Roberts Hannah, Flores David S C, Cutler Antony J, Brown Andrew C, Whalley Justin P, Mielczarek Olga, Buck David, Lockstone Helen, Xella Barbara, Oliver Karen, Corton Craig, Betteridge Emma, Bashford-Rogers Rachael, Knight Julian C, Todd John A, Band Gavin

Abstract excerpt

Driven by the necessity to survive environmental pathogens, the human immune system has evolved exceptional diversity and plasticity, to which several factors contribute including inheritable structural polymorphism of the underlying genes. Characterizing this variation is challenging due to the complexity of these loci, which contain extensive regions of paralogy, segmental duplication and high copy-number...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34343164
DOI: 10.1371/journal.pcbi.1009254
PMCID: PMC8363018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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