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Article

Epistatic interactions promote persistence of NS3-Q80K in HCV infection by compensating for protein folding instability.

The Journal of biological chemistry - 1 Sept 2021

Dultz Georg, Srikakulam Sanjay K, Konetschnik Michael, Shimakami Tetsuro, Doncheva Nadezhda T, Dietz Julia, Sarrazin Christoph, Biondi Ricardo M, Zeuzem Stefan, Tampé Robert, Kalinina Olga V, Welsch Christoph

Abstract excerpt

The Q80K polymorphism in the NS3-4A protease of the hepatitis C virus is associated with treatment failure of direct-acting antiviral agents. This polymorphism is highly prevalent in genotype 1a infections and stably transmitted between hosts. Here, we investigated the underlying molecular mechanisms of evolutionarily conserved coevolving amino acids in NS3-Q80K and revealed potential implications of epistatic...

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Share to Amino Acid Substitution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Identifiers

PMID: 34339738
DOI: 10.1016/j.jbc.2021.101031
PMCID: PMC8405986

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