Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conflicting selection pressures target the NS3 protein in hepatitis C virus genotypes 1a and 1b.

Virus research - 1 Feb 2010

Irausquin Stephanie Jiménez, Hughes Austin L

Abstract excerpt

Analysis of complete polyprotein-encoding sequences of the two most prevalent genotypes of hepatitis C virus (HCV-1a and HCV-1b) revealed evidence of abundant, slightly deleterious nonsynonymous variants subject to ongoing purifying selection. In the case of both HCV-1a and HCV-1b, the NS3 protein demonstrated a high incidence of forward-and-backward or parallel nonsynonymous changes in CTL epitopes as measured...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Biological
Share to Amino Acid Substitution
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Hepacivirus

Share to Mutation, Missense

Share to Selection, Genetic

Share to Viral Nonstructural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19896990
DOI: 10.1016/j.virusres.2009.11.001
PMCID: PMC3529174

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conflicting selection pressures target the NS3 protein in hepatitis C virus genotypes 1a and 1b.PMID 19896990Read ↗

Distinctive pattern of sequence polymorphism in the NS3 protein of hepatitis C virus type 1b reflects conflicting evolutionary pressures.Semantic proximity Read ↗

Sequence variation in the gene encoding the nonstructural 3 protein of hepatitis C virus: evidence for immune selection.Semantic proximity Read ↗

Analysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population LevelSemantic proximity Read ↗

Comparative Analysis of Within-Host Mutation Patterns and Diversity of Hepatitis C Virus Subtypes 1a, 1b, and 3a.Semantic proximity Read ↗

Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressure.Semantic proximity Read ↗

Statistical linkage analysis of substitutions in patient-derived sequences of genotype 1a hepatitis C virus nonstructural protein 3 exposes targets for immunogen design.Semantic proximity Read ↗

Genetic heterogeneity of the NS3 protease gene in hepatitis C virus genotype 1 from untreated infected patients.Semantic proximity Read ↗

Positive selection of cytotoxic T lymphocyte escape variants during acute hepatitis C virus infectionSemantic proximity Read ↗

Full-length characterization of hepatitis C virus subtype 3a reveals novel hypervariable regions under positive selection during acute infection.Semantic proximity Read ↗

Comparative analysis of variation and selection in the HCV genome.Semantic proximity Read ↗

Evolutionary dynamics of hepatitis C virus envelope genes during chronic infection.Semantic proximity Read ↗

Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.