Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV-1 protease catalytic efficiency effects caused by random single amino acid substitutions.

Molecular biology and evolution - 1 Feb 2007

Parera Mariona, Fernàndez Guerau, Clotet Bonaventura, Martínez Miguel Angel

Abstract excerpt

Protein evolution has occurred by successive fixation of individual mutations. The probability of fixation depends on the fitness of the mutation, and the arising variant can be deleterious, neutral, or beneficial. Despite its relevance, only few studies have estimated the distribution of fitness effects caused by random single mutations on protein function. The human immunodeficiency virus type 1 (HIV-1)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Catalysis
Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Gene Library

Share to HIV Protease

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 17090696
DOI: 10.1093/molbev/msl168
PMCID: PMC7107532

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV-1 protease catalytic efficiency effects caused by random single amino acid substitutions.PMID 17090696Read ↗

Epistasis as a determinant of the HIV-1 protease's robustness to mutation.Semantic proximity Read ↗

Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 proteaseSemantic proximity Read ↗

Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease.Semantic proximity Read ↗

The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virus.Semantic proximity Read ↗

Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded.Semantic proximity Read ↗

Distribution of fitness effects caused by single-nucleotide substitutions in bacteriophage f1.Semantic proximity Read ↗

Fitness landscape of human immunodeficiency virus type 1 protease quasispecies.Semantic proximity Read ↗

Fitness epistasis and constraints on adaptation in a human immunodeficiency virus type 1 protein region.Semantic proximity Read ↗

Effects of random mutations in the human immunodeficiency virus type 1 transcriptional promoter on viral fitness in different host cell environments.Semantic proximity Read ↗

A biophysical protein folding model accounts for most mutational fitness effects in viruses.Semantic proximity Read ↗

Mutation induced extinction in finite populations: lethal mutagenesis and lethal isolation.Semantic proximity Read ↗

Distribution of fitness and virulence effects caused by single-nucleotide substitutions in Tobacco Etch virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.