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Article

Divergent folding-mediated epistasis among unstable membrane protein variants.

eLife - 30 Jul 2024

Chamness Laura M, Kuntz Charles P, McKee Andrew G, Penn Wesley D, Hemmerich Christopher M, Rusch Douglas B, Woods Hope, Dyotima, Meiler Jens, Schlebach Jonathan P

Abstract excerpt

Many membrane proteins are prone to misfolding, which compromises their functional expression at the plasma membrane. This is particularly true for the mammalian gonadotropin-releasing hormone receptor GPCRs (GnRHR). We recently demonstrated that evolutionary GnRHR modifications appear to have coincided with adaptive changes in cotranslational folding efficiency. Though protein stability is known to shape...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39078397
DOI: 10.7554/eLife.92406
PMCID: PMC11288631

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