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Article

Global origin and transmission of hepatitis C virus nonstructural protein 3 Q80K polymorphism.

The Journal of infectious diseases - 15 Apr 2015

McCloskey Rosemary M, Liang Richard H, Joy Jeffrey B, Krajden Mel, Montaner Julio S G, Harrigan P Richard, Poon Art F Y

Abstract excerpt

Hepatitis C virus (HCV) has a naturally occurring polymorphism, Q80K, in the nonstructural protein 3 (NS3) gene encoding the viral protease, which has been associated with reduced susceptibility to the direct-acting antiviral inhibitor simeprevir. Q80K is observed predominantly in HCV genotype 1a and seldom in other HCV genotypes; moreover, it has a markedly high prevalence in the United States. Here, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25389307
DOI: 10.1093/infdis/jiu613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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