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Article

Natural HCV variants with increased replicative fitness due to NS3 helicase mutations in the C-terminal helix α18.

Scientific reports - 20 Jan 2016

Stross Claudia, Shimakami Tetsuro, Haselow Katrin, Ahmad Monazza Q, Zeuzem Stefan, Lange Christian M, Welsch Christoph

Abstract excerpt

High replicative fitness is a general determinant of a multidrug resistance phenotype and may explain lower sensitivity to direct-acting antiviral agents (DAAs) in some hepatitis C virus genotypes. Genetic diversity in the molecular target site of peptidomimetic NS3 protease inhibitors could impact variant replicative fitness and potentially add to virologic treatment failure. We selected NS3 helicase residues...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26787124
DOI: 10.1038/srep19526
PMCID: PMC4726148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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