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Article

Ketoamide resistance and hepatitis C virus fitness in val55 variants of the NS3 serine protease.

Antimicrobial agents and chemotherapy - 1 Apr 2012

Welsch Christoph, Schweizer Sabine, Shimakami Tetsuro, Domingues Francisco S, Kim Seungtaek, Lemon Stanley M, Antes Iris

Abstract excerpt

Drug-resistant viral variants are a major issue in the use of direct-acting antiviral agents in chronic hepatitis C. Ketoamides are potent inhibitors of the NS3 protease, with V55A identified as mutation associated with resistance to boceprevir. Underlying molecular mechanisms are only partially understood. We applied a comprehensive sequence analysis to characterize the natural variability at Val55 within...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22252823
DOI: 10.1128/AAC.05184-11
PMCID: PMC3318394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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