Article
Host proteostasis modulates influenza evolution.
eLife - 26 Sept 2017
Phillips Angela M, Gonzalez Luna O, Nekongo Emmanuel E, Ponomarenko Anna I, McHugh Sean M, Butty Vincent L, Levine Stuart S, Lin Yu-Shan, Mirny Leonid A, Shoulders Matthew D
Abstract excerpt
Predicting and constraining RNA virus evolution require understanding the molecular factors that define the mutational landscape accessible to these pathogens. RNA viruses typically have high mutation rates, resulting in frequent production of protein variants with compromised biophysical properties. Their evolution is necessarily constrained by the consequent challenge to protein folding and function. We...
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