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Article

Reduced TGF‐β Expression and CD206‐Positive Resident Macrophages in the Intervertebral Discs of Aged Mice

1 Jan 2021

Abstract excerpt

Age is a key factor in intervertebral disc (IVD) degeneration; however, the changes that occur in IVDs with age are not fully understood. Tissue‐resident macrophages are critical for tissue homeostasis and are regulated by transforming growth factor‐ (TGF‐) β. We examined changes in the proportion of resident macrophages in young versus aged mice and the role of TGF‐β in regulating resident macrophages in IVDs....

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Share to Spine and Intervertebral Disc Pathology
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PMID: 34337052
DOI: 10.1155/2021/7988320

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