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Article

Macrophage phenotypes and monocyte subsets after destabilization of the medial meniscus in mice.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Oct 2021

Utomo Lizette, Fahy Niamh, Kops Nicole, van Tiel Sandra T, Waarsing Jan, Verhaar Jan A N, Leenen Pieter J M, van Osch Gerjo J V M, Bastiaansen-Jenniskens Yvonne M

Abstract excerpt

Macrophages play an important role in the development and progression of osteoarthritis (OA). The aim of this study was to identify macrophage phenotypes in synovium and monocyte subsets in peripheral blood in C57BL/6 mice by destabilizing the medial meniscus (DMM), and the association of macrophage subsets with OA features. DMM, sham, and non-operated knees were histologically assessed between 1 and 56 days for...

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Identifiers

PMID: 33336820
DOI: 10.1002/jor.24958
PMCID: PMC8518591

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