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Mechanisms and Therapeutic Strategies of Macrophage Polarization in Intervertebral Disc Degeneration

14 May 2025

Abstract excerpt

Background: Intervertebral disc degeneration (IVDD) is a leading cause of low back pain (LBP), contributing significantly to global disability and productivity loss. Its pathogenesis involves complex processes, including inflammation, cellular senescence, angiogenesis, fibrosis, neural ingrowth, and sensitization. Emerging evidence highlights macrophages as central immune regulators infiltrating degenerated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40371270
DOI: 10.1002/jsp2.70065

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