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Article

Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration.

The spine journal : official journal of the North American Spine Society - 1 Feb 2018

Nakazawa Kenneth R, Walter Benjamin A, Laudier Damien M, Krishnamoorthy Divya, Mosley Grace E, Spiller Kara L, Iatridis James C

Abstract excerpt

BACKGROUND CONTEXT: Chronic inflammation is an important component of intervertebral disc (IVD) degeneration, but there is limited knowledge about the identity and source of inflammatory cells involved with the degenerative processes. Macrophages can exhibit multiple phenotypes and are known inflammatory regulators in many tissues, but their phenotypes have not been characterized in IVD degeneration. PURPOSE: We...

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Identifiers

PMID: 29031872
DOI: 10.1016/j.spinee.2017.09.018
PMCID: PMC5815908

Genes

IVD
CCR7

Provenance

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