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Article

Dissecting the role of myeloid and mesenchymal fibroblasts in age-dependent cardiac fibrosis.

Basic research in cardiology - 1 Jul 2017

Trial JoAnn, Heredia Celia Pena, Taffet George E, Entman Mark L, Cieslik Katarzyna A

Abstract excerpt

Aging is associated with increased cardiac interstitial fibrosis and diastolic dysfunction. Our previous study has shown that mesenchymal fibroblasts in the C57BL/6J (B6J) aging mouse heart acquire an inflammatory phenotype and produce higher levels of chemokines. Monocyte chemoattractant protein-1 (MCP-1) secreted by these aged fibroblasts promotes leukocyte uptake into the heart. Some of the monocytes that...

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Identifiers

PMID: 28478479
DOI: 10.1007/s00395-017-0623-4
PMCID: PMC5591578

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