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Article

Germ-line mutations in WDR77 predispose to familial papillary thyroid cancer.

Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 2021

Zhao Yanyang, Yu Tian, Sun Jie, Wang Feiliang, Cheng Chaoze, He Shurong, Chen Lan, Xie Donghui, Fu Liping, Guan Xuhuizi, Yan An, Li Yao, Miao Gang, Zhu Xiaoquan

Abstract excerpt

The inheritance of predisposition to nonsyndromic familial nonmedullary thyroid cancer (FNMTC) remains unclear. Here, we report six individuals with papillary thyroid cancer (PTC) in two unrelated nonsyndromic FNMTC families. Whole-exome sequencing revealed two germ-line loss-of-function variants occurring within a 28-bp fragment of WDR77, which encodes a core member of a transmethylase complex formed with the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34326253
DOI: 10.1073/pnas.2026327118
PMCID: PMC8346892

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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