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Article

Clinically Relevant Germline Variants in Children With Nonmedullary Thyroid Cancer.

The Journal of clinical endocrinology and metabolism - 18 Nov 2024

van der Tuin Karin, Ruano Dina, Knijnenburg Jeroen, van der Luijt Rob B, Morreau Hans, Links Thera P, Hes Frederik J

Abstract excerpt

CONTEXT: The underlying genetic cause of nonmedullary thyroid cancer (NMTC) in children is often unknown, hampering both predictive testing of family members and preventive clinical management. OBJECTIVE: Our objectives were to investigated the potential heritability in the largest childhood NMTC cohort that has been genotyped to date. METHODS: Nationwide retrospective cohort study in tertiary referral centers....

Topics

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Adenomatous Polyposis Coli Protein
BRCA2 Protein
Checkpoint Kinase 2
DEAD-box RNA Helicases
Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ribonuclease III

Thyroid Neoplasms

Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 38415346
DOI: 10.1210/clinem/dgae107
PMCID: PMC11570363

Genes

APC
BRCA2
CHEK2
DICER1
HOXB13
MITF
SLC26A4

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