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Article

Atherosclerosis Impairs Naive CD4 T-Cell Responses via Disruption of Glycolysis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2021

Gaddis Dalia E, Padgett Lindsey E, Wu Runpei, Nguyen Anh, McSkimming Chantel, Dinh Huy Q, Araujo Daniel J, Taylor Angela M, McNamara Coleen A, Hedrick Catherine C

Abstract excerpt

Objective: CD4 T cells are important regulators of atherosclerotic progression. The metabolic profile of CD4 T cells controls their signaling and function, but how atherosclerosis affects T-cell metabolism is unknown. Here, we sought to determine the impact of atherosclerosis on CD4 T-cell metabolism and the contribution of such metabolic alterations to atheroprogression. Approach and Results: Using PCR arrays,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

Share to Diet, Western

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Share to Mice, Knockout, ApoE

Share to Plaque, Atherosclerotic

Source

Open in PubMed Open full text

Identifiers

PMID: 34320835
DOI: 10.1161/ATVBAHA.120.314189
PMCID: PMC10206822

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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