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Article

Diet-induced dyslipidemia induces metabolic and migratory adaptations in regulatory T cells.

Cardiovascular research - 23 Apr 2021

Amersfoort Jacob, Schaftenaar Frank H, Douna Hidde, van Santbrink Peter J, van Puijvelde Gijs H M, Slütter Bram, Foks Amanda C, Harms Amy, Moreno-Gordaliza Estefania, Wang Yanyan, Hankemeier Thomas, Bot Ilze, Chi Hongbo, Kuiper Johan

Abstract excerpt

AIMS: A hallmark of advanced atherosclerosis is inadequate immunosuppression by regulatory T (Treg) cells inside atherosclerotic lesions. Dyslipidemia has been suggested to alter Treg cell migration by affecting the expression of specific membrane proteins, thereby decreasing Treg cell migration towards atherosclerotic lesions. Besides membrane proteins, cellular metabolism has been shown to be a crucial factor...

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Identifiers

PMID: 32653923
DOI: 10.1093/cvr/cvaa208
PMCID: PMC8064436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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