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Article

Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis.

The Journal of clinical investigation - 1 Sept 2016

Cheng Hsin-Yuan, Gaddis Dalia E, Wu Runpei, McSkimming Chantel, Haynes LaTeira D, Taylor Angela M, McNamara Coleen A, Sorci-Thomas Mary, Hedrick Catherine C

Abstract excerpt

ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol accumulation and alters T cell homeostasis, which may contribute to progression of atherosclerosis. Here, we investigated how the selective loss of ABCG1 in T cells impacts atherosclerosis in LDL receptor-deficient (LDLR-deficient) mice, a model of the disease. In LDLR-deficient mice fed a high-cholesterol diet, T cell-specific ABCG1 deficiency...

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Source

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Identifiers

PMID: 27482882
DOI: 10.1172/JCI83136
PMCID: PMC5004951

Genes

ABCG1
LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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