Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density lipoprotein.

doi:10.1007/s00109-020-01915-w

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Article

Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density lipoprotein.

Journal of molecular medicine (Berlin, Germany) - 1 Jun 2020

Keating Samuel T, Groh Laszlo, Thiem Kathrin, Bekkering Siroon, Li Yang, Matzaraki Vasiliki, van der Heijden Charlotte D C C, van Puffelen Jelmer H, Lachmandas Ekta, Jansen Trees, Oosting Marije, de Bree L Charlotte J, Koeken Valerie A C M, Moorlag Simone J C F M, Mourits Vera P, van Diepen Janna, Strienstra Rinke, Novakovic Boris, Stunnenberg Hendrik G, van Crevel Reinout, Joosten Leo A B, Netea Mihai G, Riksen Niels P

Abstract excerpt

Stimulation of monocytes with microbial and non-microbial products, including oxidized low-density lipoprotein (oxLDL), induces a protracted pro-inflammatory, atherogenic phenotype sustained by metabolic and epigenetic reprogramming via a process called trained immunity. We investigated the intracellular metabolic mechanisms driving oxLDL-induced trained immunity in human primary monocytes and observed...

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Identifiers

PMID: 32350546
DOI: 10.1007/s00109-020-01915-w
PMCID: PMC7297856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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