Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation.

doi:10.1161/CIRCRESAHA.119.316206

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Article

Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation.

Circulation research - 8 May 2020

Schnitzler Johan G, Hoogeveen Renate M, Ali Lubna, Prange Koen H M, Waissi Farahnaz, van Weeghel Michel, Bachmann Julian C, Versloot Miranda, Borrelli Matthew J, Yeang Calvin, De Kleijn Dominique P V, Houtkooper Riekelt H, Koschinsky Marlys L, de Winther Menno P J, Groen Albert K, Witztum Joseph L, Tsimikas Sotirios, Stroes Erik S G, Kroon Jeffrey

Abstract excerpt

RATIONALE: Patients with elevated levels of lipoprotein(a) [Lp(a)] are hallmarked by increased metabolic activity in the arterial wall on positron emission tomography/computed tomography, indicative of a proinflammatory state. OBJECTIVE: We hypothesized that Lp(a) induces endothelial cell inflammation by rewiring endothelial metabolism. METHODS AND RESULTS: We evaluated the impact of Lp(a) on the endothelium and...

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Identifiers

PMID: 32160811
DOI: 10.1161/CIRCRESAHA.119.316206
PMCID: PMC7208285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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