Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decreased recent adaptation at human mendelian disease genes as a possible consequence of interference between advantageous and deleterious variants.

eLife - 12 Oct 2021

Di Chenlu, Murga Moreno Jesus, Salazar-Tortosa Diego F, Lauterbur M Elise, Enard David

Abstract excerpt

Advances in genome sequencing have improved our understanding of the genetic basis of human diseases, and thousands of human genes have been associated with different diseases. Recent genomic adaptation at disease genes has not been well characterized. Here, we compare the rate of strong recent adaptation in the form of selective sweeps between mendelian, non-infectious disease genes and non-disease genes across...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Databases, Genetic
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Diseases, Inborn

Share to Genetic Variation

Share to Genome, Human

Source

Open in PubMed Open full text

Identifiers

PMID: 34636724
DOI: 10.7554/eLife.69026
PMCID: PMC8526059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decreased recent adaptation at human mendelian disease genes as a possible consequence of interference between advantageous and deleterious variants.PMID 34636724Read ↗

Decreased adaptation at human disease genes as a possible consequence of interference between advantageous and deleterious variantsSemantic proximity Read ↗

Polygenic patterns of adaptive introgression in modern humans are mainly shaped by response to pathogensSemantic proximity Read ↗

Obstruction of adaptation in diploids by recessive, strongly deleterious alleles.Semantic proximity Read ↗

Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes.Semantic proximity Read ↗

Soft sweeps are the dominant mode of adaptation in the human genomeSemantic proximity Read ↗

Classic selective sweeps were rare in recent human evolution.Semantic proximity Read ↗

Challenges in human genetic diversity: demographic history and adaptation.Semantic proximity Read ↗

Distance from Sub-Saharan Africa Predicts Mutational Load in Diverse Human GenomesSemantic proximity Read ↗

Soft Sweeps Are the Dominant Mode of Adaptation in the Human Genome.Semantic proximity Read ↗

Genetic variation and adaptation in Africa: implications for human evolution and disease.Semantic proximity Read ↗

Distance from sub-Saharan Africa predicts mutational load in diverse human genomes.Semantic proximity Read ↗

Neanderthal introgressed ancestry reveals human genomic regions enriched with recessive deleterious mutationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.