Article
Dual Modes of Gene Regulation by CDK12
2025-09-23
Abstract excerpt
The process of transcription is driven forward by the activity of kinases including CDK7, CDK9 and CDK12. Accordingly, acute inhibition of any of these kinases results in profound downregulation of gene expression. Here, we discover that loss or inhibition of CDK12 also significantly upregulates a set of coding and non-coding loci, whose activation could contribute to the anti-proliferative effects of CDK12 inhibi...
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Identifiers and source
- Literature Corpus work
- 430c74d4-e5bd-5b69-be30-f95a3aa03c28
- DOI
- 10.1101/2025.09.22.677923