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A review on the role of cyclin dependent kinases in cancers

20 Oct 2022

Abstract excerpt

The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers. The expression of CDKs is controlled by a complex regulatory network comprised of genetic and epigenetic mechanisms, which are dysregulated during the progression of cancer. The abnormal activation of CDKs results in uncontrolled...

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PMID: 36266723
DOI: 10.1186/s12935-022-02747-z

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