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Article

Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans.

Aging - 1 Oct 2010

Rahman Mohammad M, Stuchlick Olga, El-Karim Enas G, Stuart Ryan, Kipreos Edward T, Wells Lance

Abstract excerpt

O-linked-β-N-acetylglucosamine (O-GlcNAc) modification is a regulatory, nuclear and cytoplasmic post-translational glycosylation of proteins associated with age-related diseases such as Alzheimer's, Parkinson's, and type II diabetes. Global elevation of O-GlcNAc levels on intracellular proteins can induce insulin resistance, the hallmark of type II diabetes, in mammalian systems. InC. elegans, attenuation of the...

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Source

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Identifiers

PMID: 20952811
DOI: 10.18632/aging.100208
PMCID: PMC2993798

Genes

OGA
OGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans.PMID 20952811Read ↗

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