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Article

Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2009

Arechiga Adrian F, Habib Tania, He Yantao, Zhang Xian, Zhang Zhong-Yin, Funk Andrew, Buckner Jane H

Abstract excerpt

PTPN22 is a gene encoding the protein tyrosine phosphatase Lyp. A missense mutation changing residue 1858 from cytosine to thymidine (1858C/T) is associated with multiple autoimmune disorders. Studies have demonstrated that Lyp has an inhibitory effect on TCR signaling; however, the presence of autoantibodies in all of the diseases associated with the 1858T variant and recent evidence that Ca(2+) flux is altered...

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Topics

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Share to Alleles
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immunologic Memory

Share to Lymphocyte Activation

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Share to Receptors, Antigen, B-Cell

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Source

Open in PubMed Open full text

Identifiers

PMID: 19265110
DOI: 10.4049/jimmunol.0713370
PMCID: PMC2797545

Genes

PTPN22
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling.PMID 19265110Read ↗

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Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.Semantic proximity Read ↗

Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4+ T Cell Activation.Semantic proximity Read ↗

Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant.Semantic proximity Read ↗

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.Semantic proximity Read ↗

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