Article
The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses.
Human immunology - 1 May 2013
Vang Torkel, Landskron Johannes, Viken Marte K, Oberprieler Nikolaus, Torgersen Knut M, Mustelin Tomas, Tasken Kjetil, Tautz Lutz, Rickert Robert C, Lie Benedicte A
Abstract excerpt
The C1858T single nucleotide polymorphism in PTPN22, which is the gene encoding lymphoid tyrosine phosphatase (LYP), confers increased risk for various autoimmune disorders in Caucasians. Although the disease-associated LYP allele (LYP*W620) is a gain-of-function variant that has higher catalytic activity than the major allele (LYP*R620), it is still unclear how LYP*W620 predisposes for autoimmunity. Here, we...
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