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Activation-Induced Cytidine Deaminase Accelerates Clonal Evolution in <i>BCR-ABL1</i> –Driven B-Cell Lineage Acute Lymphoblastic Leukemia

28 Sept 2010

Abstract excerpt

Activation-induced cytidine deaminase (AID) is required for somatic hypermutation and immunoglobulin (Ig) class switch recombination in germinal center (GC) B cells. Occasionally, AID can target non-Ig genes and thereby promote GC B-cell lymphomagenesis. We recently showed that the oncogenic BCR-ABL1 kinase induces aberrant expression of AID in pre-B acute lymphoblastic leukemia (ALL) and lymphoid chronic...

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PMID: 20876806
DOI: 10.1158/0008-5472.can-10-1438

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