Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma

doi:10.1073/pnas.212410199

Article

Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma

14 Oct 2002

Abstract excerpt

The TCL1 protooncogene is overexpressed in many mature B cell lymphomas, especially from AIDS patients. To determine whether aberrant expression promotes B cell transformation, we generated a murine model in which a TCL1 transgene was overexpressed at similar levels in both B and T cells. Strikingly, transgenic mice developed Burkitt-like lymphoma (BLL) and diffuse large B cell lymphoma (DLBCL) with attendant...

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