Article

Active Surveillance Characterizes Human Intratumoral T Cell Exhaustion

2021-05-07

Abstract excerpt

Intratumoral T cells that might otherwise control tumors are often identified in an ‘exhausted’ state, defined by specific epigenetic modifications as well as upregulation of genes such as CD38, CTLA-4 and PD-1. While the term might imply inactivity, there has been little study of this state at the phenotypic level in tumors to understand the extent of their incapacitation. Starting with the observation that T cel...

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Literature Corpus work: c7afba79-f4ef-5864-b4ea-c0acfcd4f12f
DOI: 10.1101/2021.05.06.443033

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