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Article

Differences in TCR repertoire and T cell activation underlie the divergent outcomes of antitumor immune responses in tumor-eradicating versus tumor-progressing hosts.

Journal for immunotherapy of cancer - 1 Jan 2021

Woolaver Rachel A, Wang Xiaoguang, Krinsky Alexandra L, Waschke Brittany C, Chen Samantha M Y, Popolizio Vince, Nicklawsky Andrew G, Gao Dexiang, Chen Zhangguo, Jimeno Antonio, Wang Xiao-Jing, Wang Jing Hong

Abstract excerpt

BACKGROUND: Antitumor immunity is highly heterogeneous between individuals; however, underlying mechanisms remain elusive, despite their potential to improve personalized cancer immunotherapy. Head and neck squamous cell carcinomas (HNSCCs) vary significantly in immune infiltration and therapeutic responses between patients, demanding a mouse model with appropriate heterogeneity to investigate mechanistic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocytes, Tumor-Infiltrating

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Share to Receptors, Antigen, T-Cell

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Source

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Identifiers

PMID: 33414263
DOI: 10.1136/jitc-2020-001615
PMCID: PMC7797305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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