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Article

Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia.

Cell reports - 20 Jul 2021

Gaikwad Sagar, Puangmalai Nicha, Bittar Alice, Montalbano Mauro, Garcia Stephanie, McAllen Salome, Bhatt Nemil, Sonawane Minal, Sengupta Urmi, Kayed Rakez

Abstract excerpt

Aging, pathological tau oligomers (TauO), and chronic inflammation in the brain play a central role in tauopathies, including Alzheimer's disease (AD) and frontotemporal dementia (FTD). However, the underlying mechanism of TauO-induced aging-related neuroinflammation remains unclear. Here, we show that TauO-associated astrocytes display a senescence-like phenotype in the brains of patients with AD and FTD. TauO...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34289368
DOI: 10.1016/j.celrep.2021.109419
PMCID: PMC8341760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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