Oxygen-dependent flow of sickle trait blood as an in vitro therapeutic benchmark for sickle cell disease treatments.

Abstract excerpt

Although homozygous sickle cell disease is often clinically severe, the corresponding heterozygous state, sickle cell trait, is almost completely benign despite the fact that there is only a modest difference in sickle hemoglobin levels between the two conditions. In both conditions, hypoxia can lead to polymerization of sickle hemoglobin, changes in red cell mechanical properties, and impaired blood flow. Here,...

Topics

• Anemia, Sickle Cell
• Benchmarking
• Blood Flow Velocity
• Blood Viscosity
• Equipment Design
• Exchange Transfusion, Whole Blood
• Hemoglobin, Sickle
• Humans
• In Vitro Techniques
• Lab-On-A-Chip Devices
• Oxygen
• Phenotype
• Shear Strength
• Sickle Cell Trait