Article

Biophysical Basis of Hb-S Polymerization in Red Blood Cell Sickling

2019-06-21

Abstract excerpt

<h4>ABSTRACT</h4> Sickle cell disease (SCD) is an autosomal recessive genetic disease caused by the Glu6Val mutation in the β chain (Hb) of the oxygen-carrying hemoglobin protein in sicklemia patients. In the molecular pathogenesis of SCD, the sickle hemoglobin (Hb-S) polymerization is a major driver for structural deformation of red blood cells, i.e. red blood cell (RBC) sickling. Biophysically, it still remains...

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Literature Corpus work: 49e8dd5e-f715-5722-9d2c-116fa1cb45ba
DOI: 10.1101/676957

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