Article
Kinetics of sickle cell biorheology and implications for painful vasoocclusive crisis.
Proceedings of the National Academy of Sciences of the United States of America - 3 Feb 2015
Du E, Diez-Silva Monica, Kato Gregory J, Dao Ming, Suresh Subra
Abstract excerpt
We developed a microfluidics-based model to quantify cell-level processes modulating the pathophysiology of sickle cell disease (SCD). This in vitro model enabled quantitative investigations of the kinetics of cell sickling, unsickling, and cell rheology. We created short-term and long-term hypoxic conditions to simulate normal and retarded transit scenarios in microvasculature. Using blood samples from 25 SCD...
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