Article
Structure-Function Relations of Human Hemoglobins
1 Jul 2006
Abstract excerpt
In 1949 Pauling and his associates showed that sickle cell hemoglobin (HbS) belonged to an abnormal molecular species. In 1958 Ingram, who used a two-dimensional system of electrophoresis and chromatography to break down the hemoglobin molecule into a mixture of smaller peptides, defined the molecular defect in HbS by showing that it differed from normal adult hemoglobin by only a single peptide. Since then, more...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.