Article
Smoking accelerates renal cystic disease and worsens cardiac phenotype in Pkd1-deficient mice.
Scientific reports - 14 Jul 2021
Sousa Marciana V, Amaral Andressa G, Freitas Jessica A, Murata Gilson M, Watanabe Elieser H, Balbo Bruno E, Tavares Marcelo D, Hortegal Renato A, Rocon Camila, Souza Leandro E, Irigoyen Maria C, Salemi Vera M, Onuchic Luiz F
Abstract excerpt
Smoking has been associated with renal disease progression in ADPKD but the underlying deleterious mechanisms and whether it specifically worsens the cardiac phenotype remain unknown. To investigate these matters, Pkd1-deficient cystic mice and noncystic littermates were exposed to smoking from conception to 18 weeks of age and, along with nonexposed controls, were analyzed at 13-18 weeks. Renal cystic index and...
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