Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Translational research in ADPKD: lessons from animal models.

Nature reviews. Nephrology - 1 Oct 2014

Happé Hester, Peters Dorien J M

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or PKD2, which encode polycystin-1 and polycystin-2, respectively. Rodent models are available to study the pathogenesis of polycystic kidney disease (PKD) and for preclinical testing of potential therapies-either genetically engineered models carrying mutations in Pkd1 or Pkd2 or models of renal cystic disease that do not have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Disease Progression
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Mutation

Share to Polycystic Kidney, Autosomal Dominant

Share to TRPP Cation Channels

Source

Identifiers

PMID: 25137562
DOI: 10.1038/nrneph.2014.137

Genes

PKD1
PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Translational research in ADPKD: lessons from animal models.PMID 25137562Read ↗

Review of the Use of Animal Models of Human Polycystic Kidney Disease for the Evaluation of Experimental Therapeutic ModalitiesSemantic proximity Read ↗

Tubular obstruction induced polycystin upregulation is pro-fibrotic and induced a severe cystic phenotype in adult mice with autosomal dominant polycystic kidney disease: the coexistence of polycystin loss and gain function in ADPKDSemantic proximity Read ↗

Kidney: polycystic kidney diseaseSemantic proximity Read ↗

Experimental Models of Polycystic Kidney Disease: Applications and Therapeutic TestingSemantic proximity Read ↗

Genetics and Pathogenesis of Polycystic Kidney DiseaseSemantic proximity Read ↗

Molecular pathogenesis of ADPKD: the polycystin complex gets complex.Semantic proximity Read ↗

Autosomal dominant polycystic kidney disease: Disrupted pathways and potential therapeutic interventions.Semantic proximity Read ↗

Fundamental insights into autosomal dominant polycystic kidney disease from human-based cell models.Semantic proximity Read ↗

Molecular and cellular pathophysiology of autosomal recessive polycystic kidney disease (ARPKD).Semantic proximity Read ↗

The etiology, pathogenesis, and treatment of autosomal dominant polycystic kidney disease: recent advances.Semantic proximity Read ↗

Autosomal dominant polycystic kidney disease: clues to pathogenesis.Semantic proximity Read ↗

Pathophysiology of childhood polycystic kidney diseases: new insights into disease-specific therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.