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Article

PKD1 mono-allelic knockout is sufficient to trigger renal cystogenesis in a mini-pig model.

International journal of biological sciences - 1 Jan 2015

He Jin, Li Qiuyan, Fang Suyun, Guo Ying, Liu Tongxin, Ye Jianhua, Yu Zhengquan, Zhang Ran, Zhao Yaofeng, Hu Xiaoxiang, Bai Xueyuan, Chen Xiangmei, Li Ning

Abstract excerpt

PKD1 and PKD2 mutations could lead to autosomal dominant polycystic kidney disease (ADPKD), which afflicts millions of people worldwide. Due to the marked differences in the lifespan, size, anatomy, and physiology from humans, rodent ADPKD models cannot fully mimic the disease. To obtain a large animal model that recapitulates the disease, we constructed a mini-pig model by mono-allelic knockout (KO) of PKD1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25798056
DOI: 10.7150/ijbs.10858
PMCID: PMC4366635

Genes

PKD1
PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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