Article
Reversible cystogenesis in juvenile primate ADPKD models: evidence from PKD1 heterozygous monkeys.
Human molecular genetics - 23 Feb 2026
Matsumoto Shoma, Morimura Toshifumi, Kobayashi Kenichi, Tsuji Keiichi, Nakaya Masataka, Tsukiyama Tomoyuki, Kawamoto Ikuo, Nakagawa Takahiro, Morishige Etsuko, Fukuda Koji, Iwakiri Teppei, Nozaki Kazuhiko, Kawauchi Akihiro, Kageyama Susumu, Kume Shinji, Nishio Saori, Itoh Yasushi, Ema Masatsugu
Abstract excerpt
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder caused predominantly by heterozygous mutations in the PKD1 gene, leading to progressive renal cyst formation. While PKD1 mutant mouse models have provided mechanistic insights, PKD1 heterozygous mice fail to replicate the early cystogenesis observed in human patients. To address this gap, we conducted a longitudinal study using...
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