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Article

Overexpression of TGF-β1 induces renal fibrosis and accelerates the decline in kidney function in polycystic kidney disease.

American journal of physiology. Renal physiology - 1 Dec 2020

Zhang Yan, Dai Yuqiao, Raman Archana, Daniel Emily, Metcalf July, Reif Gail, Pierucci-Alves Fernando, Wallace Darren P

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the presence of numerous fluid-filled cysts, extensive fibrosis, and the progressive decline in kidney function. Transforming growth factor-β1 (TGF-β1), an important mediator for renal fibrosis and chronic kidney disease, is overexpressed by cystic cells compared with normal kidney cells; however, its role in PKD pathogenesis remains...

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Identifiers

PMID: 33166182
DOI: 10.1152/ajprenal.00366.2020
PMCID: PMC7792699

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SMAD3

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