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Article

PKD1 deficiency induces Bronchiectasis in a porcine ADPKD model.

Respiratory research - 29 Oct 2022

Wang Runming, Li Wenya, Dai Haiting, Zhu Mingli, Li Lingyu, Si Guohui, Bai Yilina, Wu Hanyu, Hu Xiaoxiang, Xing Yiming

Abstract excerpt

BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent genetic disorder, mainly characterized by the development of renal cysts, as well as various extrarenal manifestations. Previous studies have shown that ADPKD is related to bronchiectasis, while its pathogenic mechanism is unclear. In previous studies, we have generated the PKD1+/- pigs to simulate the progression of cyst formation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36309681
DOI: 10.1186/s12931-022-02214-3
PMCID: PMC9617414

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