Article

Effective assessment of CD4 <sup>+</sup> T cell Immunodominance patterns: impact of antigen processing and HLA restriction

2024-01-10

Abstract excerpt

Identifying T cell epitopes is essential for studying and potentially tuning immune responses to pathogens. The polymorphic nature of major histocompatibility complex of class II (MHCII)-genes, and the complexity of the antigen processing mechanisms hinders the effective prediction of immunodominant patterns in humans, specially at the population level. Here, we combined the output of a reconstituted antigen proce...

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Literature Corpus work: 13876a49-fa14-59e5-950e-74db51a0fee0
DOI: 10.1101/2024.01.10.574975

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