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Article

Immune activation promotes evolutionary conservation of T-cell epitopes in HIV-1.

PLoS biology - 1 Jan 2013

Sanjuán Rafael, Nebot Miguel R, Peris Joan B, Alcamí José

Abstract excerpt

The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope...

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Share to Conserved Sequence
Share to Epitopes, T-Lymphocyte
Share to HIV Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immune Evasion

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Source

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Identifiers

PMID: 23565057
DOI: 10.1371/journal.pbio.1001523
PMCID: PMC3614509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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