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Article

Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance.

Nature immunology - 1 Jun 2009

Tenzer Stefan, Wee Edmund, Burgevin Anne, Stewart-Jones Guillaume, Friis Lone, Lamberth Kasper, Chang Chih-hao, Harndahl Mikkel, Weimershaus Mirjana, Gerstoft Jan, Akkad Nadja, Klenerman Paul, Fugger Lars, Jones E Yvonne, McMichael Andrew J, Buus Søren, Schild Hansjörg, van Endert Peter, Iversen Astrid K N

Abstract excerpt

Although cytotoxic T lymphocytes (CTLs) in people infected with human immunodeficiency virus type 1 can potentially target multiple virus epitopes, the same few are recognized repeatedly. We show here that CTL immunodominance in regions of the human immunodeficiency virus type 1 group-associated antigen proteins p17 and p24 correlated with epitope abundance, which was strongly influenced by proteasomal digestion...

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Share to HIV Core Protein p24
Share to Antigen Presentation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

Share to HIV Antigens

Share to HLA-A Antigens

Share to Immunodominant Epitopes

Share to Major Histocompatibility Complex

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 19412183
DOI: 10.1038/ni.1728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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