Article
Extensive HLA class I allele promiscuity among viral CTL epitopes.
European journal of immunology - 1 Sept 2007
Frahm Nicole, Yusim Karina, Suscovich Todd J, Adams Sharon, Sidney John, Hraber Peter, Hewitt Hannah S, Linde Caitlyn H, Kavanagh Daniel G, Woodberry Tonia, Henry Leah M, Faircloth Kellie, Listgarten Jennifer, Kadie Carl, Jojic Nebojsa, Sango Kaori, Brown Nancy V, Pae Eunice, Zaman M Tauheed, Bihl Florian, Khatri Ashok, John Mina, Mallal Simon, Marincola Francesco M, Walker Bruce D, Sette Alessandro, Heckerman David, Korber Bette T, Brander Christian
Abstract excerpt
Promiscuous binding of T helper epitopes to MHC class II molecules has been well established, but few examples of promiscuous class I-restricted epitopes exist. To address the extent of promiscuity of HLA class I peptides, responses to 242 well-defined viral epitopes were tested in 100 subjects regardless of the individuals' HLA type. Surprisingly, half of all detected responses were seen in the absence of the...
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