Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human herpesvirus diversity is altered in HLA class I binding peptides.

Proceedings of the National Academy of Sciences of the United States of America - 3 May 2022

Palmer William H, Telford Marco, Navarro Arcadi, Santpere Gabriel, Norman Paul J

Abstract excerpt

Herpesviruses are ubiquitous, genetically diverse DNA viruses, with long-term presence in humans associated with infrequent but significant pathology. Human leukocyte antigen (HLA) class I presents intracellularly derived peptide fragments from infected tissue cells to CD8+ T and natural killer cells, thereby directing antiviral immunity. Allotypes of highly polymorphic HLA class I are distinguished by their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpesviridae

Share to Herpesvirus Infections and Treatments

Share to Histocompatibility Antigens Class I

Share to Peptides

Share to Viral-associated cancers and disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 35486690
DOI: 10.1073/pnas.2123248119
PMCID: PMC9170163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human herpesvirus diversity is altered in HLA class I binding peptides.PMID 35486690Read ↗

Immunogenetic profiles of 9 human herpes virus envelope glycoproteins.Semantic proximity Read ↗

Immunogenetics of viral infections.Semantic proximity Read ↗

Adaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs.Semantic proximity Read ↗

The C-terminal extension landscape of naturally presented HLA-I ligandsSemantic proximity Read ↗

HLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV.Semantic proximity Read ↗

Significance of variation within HIV, EBV, and KSHV subtypes.Semantic proximity Read ↗

Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1.Semantic proximity Read ↗

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.Semantic proximity Read ↗

Viruses selectively mutate their CD8+ T-cell epitopes--a large-scale immunomic analysis.Semantic proximity Read ↗

Human leukocyte antigen variation is associated with cytomegalovirus serostatus in healthy individuals.Semantic proximity Read ↗

Widespread impact of HLA restriction on immune control and escape pathways of HIV-1.Semantic proximity Read ↗

Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.