Article
ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis.
EMBO molecular medicine - 1 Feb 2014
Romagnoli Mathilde, Mineva Nora D, Polmear Michael, Conrad Catharina, Srinivasan Srimathi, Loussouarn Delphine, Barillé-Nion Sophie, Georgakoudi Irene, Dagg Áine, McDermott Enda W, Duffy Michael J, McGowan Patricia M, Schlomann Uwe, Parsons Maddy, Bartsch Jörg W, Sonenshein Gail E
Abstract excerpt
The transmembrane metalloprotease-disintegrin ADAM8 mediates cell adhesion and shedding of ligands, receptors and extracellular matrix components. Here, we report that ADAM8 is abundantly expressed in breast tumors and derived metastases compared to normal tissue, especially in triple-negative breast cancers (TNBCs). Furthermore, high ADAM8 levels predicted poor patient outcome. Consistently, ADAM8 promoted an...
Topics
- ADAM Proteins
- Animals
- Antibodies, Monoclonal
- Breast Neoplasms
- Cell Adhesion
- Cell Hypoxia
- Cell Movement
- Cell Proliferation
- Endothelial Cells
- Female