Article
Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2017
Lu Yinzhong, Wan Jun, Yang Zhifeng, Lei Xiling, Niu Qi, Jiang Lanxin, Passtoors Willemijn M, Zang Aiping, Fraering Patrick C, Wu Fang
Abstract excerpt
Deregulation of the TAM (TYRO3, AXL, and MERTK) family of receptor tyrosine kinases (RTKs) has recently been demonstrated to predominately promote survival and chemoresistance of cancer cells. Intramembrane proteolysis mediated by presenilin/γ-secretase is known to regulate the homeostasis of some RTKs. In the present study, we demonstrate that AXL, but not TYRO3 or MERTK, is efficiently and sequentially cleaved...
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