Article

Quality assessment and refinement of chromatin accessibility data using a sequence-based predictive model

2022-02-25

Abstract excerpt

Chromatin accessibility assays are central to the genome-wide identification of gene regulatory elements associated with transcriptional regulation. However, the data have highly variable quality arising from several biological and technical factors. To surmount this problem, we use the predictability of open-chromatin peaks from DNA sequence-based machine-learning models to evaluate and refine chromatin accessibi...

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Literature Corpus work: d353a54c-11c3-5b8d-b426-f4b34a5033d2
DOI: 10.1101/2022.02.24.481844

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